Utilization of Nata De Durio as a Constipation Preventive (Preliminary Animal Studies)

  • Tri Sutriani SYAM Master of Biomedical Sciences Program, Graduate School of Hasanuddin University
  • Ika Yustisia Department of Biochemistry, Faculty of Medicine, Hasanuddin University
  • Syahrijuita Kadir Department of Biochemistry, Faculty of Medicine, Hasanuddin University
  • Huhammad Husni Cangara Department of Anatomical Pathology, Hasanuddin University Hospital
  • Sartini Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University
Keywords: Constipation, defecation, fiber, nata de durio

Abstract

Constipation is a symptom/problem that arises in the process of defecation, which is not smooth and irregular due to a lack of fiber intake in the body. Nata de durio is an extracellular cellulose made from durian seeds and formed from the activity of the bacterium Acetobacter xylinum, which contains high enough fiber so that it can regulate and maintain intestinal function in the defecation process. The purpose of this study is to assess the effect of using nata de durio as a natural fiber in the defecation process in vivo and to assess its effect on the transition time of feces in the small intestine of mice. The current study was an experimental study using male mice that were given distilled water as a negative control, inulin as a positive control, and nata seed de durio with doses of 0.02 gram, 0.04 gram, and 0.08 gram as a treatment group for 5 weeks. According to the findings of this study, the administration of nata de durio had a better effect on the amount of feces, weight of feces, frequency of defecation, and consistency of feces compared to the control group. The study's conclusion is that nata de durio can be used as a natural fiber in improving the defecation pattern of BALB/c male mice.

 

References

Pradani VR, Rahfiludin MZ, Suyatno. Hubungan Asupan Serat, Lemak, dan Posisi Buang Air Besar Dengan Kejadian Konstipasi Pada Lansia. J Kesehat Masy. 2015;3(3):257-265. 2022. https://ejournal3.undip.ac.id/index.php/jkm/article/view/12156

Tumangger AF, Rahmad, Bastian F. Hubungan Tingkat Pengetahuan Tentang Serat Terhadap Sikap Mencegah Konstipasi Pada Mahasiswa Fakultas Kedokteran Universitas Abulyatama. J Med Malahayati. 2025;9(1):51-58.

Mulyani NS, Khazanah W, Febrianti S. Asupan Serat Dan Air Sebagai Faktor Risiko Konstipasi Di Kota Banda Aceh. Maj Kesehat Masy Aceh. 2019;2(1):75-82. doi:10.32672/makma.v2i1.884

Claudina I, Rahayuning DP, Kartini A. Hubungan Asupan Serat Makanan dan Cairan dengan Kejadian Konstipasi Fungsional pada Remaja di SMA Kesatrian 1 Semarang. J Kesehat Masy. 2018;6(1):486-495. http://ejournal3.undip.ac.id/index.php/jkm

Naomi R, Idrus RBH, Fauzi MB. Plant-vs. Bacterial-derived cellulose for wound healing: A review. Int J Environ Res Public Health. 2020;17(18). doi:10.3390/ijerph17186803

Santosa B, Wirawan, Muljawan RE. Pemanfaatan Molase Sebagai Sumber Karbon Alternatif Dalam Pembuatan Nata De Coco. Teknol Pangan. 2019;10(2):61-69. doi:10.35891/tp.v10i2.1641

Yustisia I, Syam TS, Kadir S. Durian Seed-Derived nata de durio: A Novel Potential Dietary Fiber for Intestinal Health and Constipation. Trop J Nat Prod Res. 2024;8(4):6918-6923. doi:10.26538/tjnpr/v8i4.24

Kusharto CM. Serat Makanan Dan Perannya Bagi Kesehatan. J Gizi dan Pangan. 2006;1(2):45-54. doi:10.25182/jgp.2006.1.2.45-54

Kuncara YA. Pengaruh Penggunaan Filtrat Kecambah Kacang Kedelai Sebagai Sumber Nitrogen Terhadap Karakteristik Nata De Soya Berbahan Dasar Limbah Tahu. Universitas Sanata Dharma; 2017.

Hua M, Fan M, Li Z, Sha J, Li S, Sun Y. Ginseng Soluble Dietary Fiber Can Regulate The Intestinal Flora Structure, Promote Colon Health, Affect Appetite and Glucolipid Metabolism in Rats. J Funct Foods. 2021;83. doi:10.1016/j.jff.2021.104534

Ardini D, Pujiwati S. Perbandingan Efektivitas Filtrat Jus Jambu Biji (Psidium guajava L.) Dan Jus Tomat (Solanum lycopersicum L) Sebagai Laksansia (Pencahar). J Kesehat. 2013;4(1):214-219. doi:10.26630/JK.V4I1.2

Yang J, Wang HP, Zhou L, Xu CF. Effect of Dietary Fiber on Constipation: A Meta Analysis. World J Gastroenterol. 2012;18(48):7378-7383. doi:10.3748/wjg.v18.i48.7378

Sunarya SR, Wardani SW, Mulyo GP. Efektivitas Pemberian Snack Bar Tape Ketan Hitam Terhadap Frekuensi Defekasi Pada Remaja Putri. J Ris Kesehat Poltekkes Depkes Bandung. 2021;13(1):283-293. doi:10.34011/juriskesbdg.v13i1.1908

Nur AF, Sukainah A, Mustarin A. Pemanfaatan Kecambah Kacang Hijau dan Kecambah Kacang Kedelai Sebagai Sumber Nitrogen dalam Pembuatan Nata de Pinnata Dari Nira Aren (Arenga Pinnata Merr.). J Pendidik Teknol Pertan. 2021;7(1):105-116. doi:10.26858/jptp.v7i1.12559

McRorie JW. Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 1: What to Look for and How to Recommend an Effective Fiber Therapy. Nutr Today. 2015;50(2):82-89. doi:10.1097/NT.0000000000000082

Lambeau K V., McRorie JW. Fiber Supplements and Clinically Proven Health Benefits: How to Recognize and Recommend an Effective Fiber Therapy. J Am Assoc Nurse Pract. 2017;29(4):216-223. doi:10.1002/2327-6924.12447

Rifna EJ, Misra NN, Dwivedi M. Recent Advances in Extraction Technologies For Recovery of Bioactive Compounds Derived From Fruit and Vegetable Waste Peels: A Review. Crit Rev Food Sci Nutr. 2021;63(6):719-752. doi:10.1080/10408398.2021.1952923

Williams BA, Mikkelsen D, Flanagan BM, Gidley MJ. “Dietary Fibre”: Moving Beyond the “Soluble/Insoluble” Classification for Monogastric Nutrition, With an Emphasis on Humans and Pigs. J Anim Sci Biotechnol. 2019;10(45):1-12. doi:10.1186/s40104-019-0350-9

Guo Z, DeLoid GM, Cao X, et al. Effects of Ingested Nanocellulose and Nanochitosan Materials on Carbohydrate Digestion and Absorption in Anin Vitrosmall Intestinal Epithelium Model. Environ Sci Nano. 2021;8(2):2554-2568. doi:10.1039/d1en00233c

Santosa B, Wignyanto W, Hidayat N, Sucipto S. Optimization of NaOH Concentration and Trichloroacetic Acid In Bacterial Carboxymethylation Cellulose. Food Res. 2020;4(3):594-601. doi:10.26656/fr.2017.4(3).370

Caro V Di, Alcamo AM, Cummings JL, et al. Effect Of Dietary Cellulose Supplementation On Gut Barrier Function And Apoptosis In A Murine Model Of Endotoxemia. PLoS One. 2019;14(12):1-13. doi:10.1371/journal.pone.0224838

Cavicchia LOA, de Almeida MEF. Health Benefits Of Kombucha: Drink and Its Biocellulose Production. Brazilian J Pharm Sci. 2022;58:1-13. doi:10.1590/s2175-97902022e20766

Hamad. Alwani, Kristiono. Pengaruh Penambahan Sumber Nitrogen Terhadap Hasil Fermentasi Nata De Coco. J Momentum. 2013;9(1):62-65.

Sutarminingsih L. Peluang Usaha Nata De Coco. Cetakan 1. Kanisius; 2004. Accessed July 8, 2025.

Wang B, Yu H, He Y, et al. Effect Of Soybean Insoluble Dietary Fiber On Prevention Of Obesity In High-Fat Diet Fed Mice Via Regulation Of The Gut Microbiota. Food Funct. 2021;12(17):7923-7937. doi:10.1039/D1FO00078K,

Published
2025-07-28
How to Cite
1.
SYAM TS, Ika Yustisia, Syahrijuita Kadir, Huhammad Husni Cangara, Sartini. Utilization of Nata De Durio as a Constipation Preventive (Preliminary Animal Studies) . woh [Internet]. 2025Jul.28 [cited 2025Aug.2];:368-75. Available from: http://103.133.36.92/index.php/woh/article/view/1136
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