The Relationship Between Nutritional Status And Insulin-Like Growth Factor-1 Levels In Stunted Children In Cirebon Regency

Siti Pandanwangi; Akrom; Nurkhasanah; Ahmad Azrul  Zuniarto; Titiek  Hidayati; Mei Ling  Tsai

doi:10.33096/woh.v7i2.1299

Siti Pandanwangi Doctoral program student, Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
Akrom Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
Nurkhasanah Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
Ahmad Azrul Zuniarto Faculty of Pharmacy, YPIB Majalengka University, Cirebon, Indonesia
Titiek Hidayati Faculty of Medicine, Muhammadiyah University, Yogyakarta, Indonesia
Mei Ling Tsai National Chenkung University Taiwan, Tainan Province, Taiwan

DOI: https://doi.org/10.33096/woh.v7i2.1299

Keywords: ELISA, kadar IGF-1, Stunting

Abstract

Insulin-like Growth Factor-1 (IGF-1) is a growth hormone mediator that acts as a growth-promoting factor in the growth process and is also an indicator of the adaptive immune system. Children who experience stunting will experience obstacles to growth and cognitive and motor development, affecting their productivity as adults. This research aims to determine IGF-1 levels and their relationship with stunted children's nutritional status. The research method used was observational, with a cross-sectional research design. The population of stunted children in the Tegalwangi locus area, Cirebon Regency, a sample of children aged 24-60 months who met the inclusion criteria of not being disabled and not being sick, was 50 children. The research began with parents filling in informed consent. Continue to fill in data on date of birth, measure height and weight, take @1ml of the child's blood, and analyze IGF-1 using the ELISA method. The research results were that the average IGF-1 level for men was 16,812 ± 5,164 ng/ml and for women 13,810 ± 5,111 ng/ml. Average IGF-1 levels aged 24-36 months were 14,777 ± 4,742 ng/ml, 36–48 months 17,050 ± 4,280 ng/ml, and 48–60 months 15,214 ± 6,248 ng/ml. Data analysis using the Pearson correlation test obtained a value of p=0.871 based on age, p=0.047 based on gender, p=0.643 based on Height for age, and p=0.245 based on Weight for age (95% CI). The conclusion is that there is a relationship between the age of a stunted child and IGF-1 levels, and there is no relationship with nutritional status. All stunted children have IGF-1 values below the standard value for normal children based on the literature, namely ≥ 28.54 ng/ml.

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