Efektivitas Suplementasi Semanggi Merah Dan Minyak Ikan Terhadap Kualitas Hidup Wanita Pascamenopause
Abstract
Menopause causes major changes in reproductive and non-reproductive tissues. Estimating that 75% of postmenopausal women experience severe complaints. Changes during the menopausal transition risk-reducing women's quality of life. Supplementation of red clover and fish oil are some supplements that are used to overcome various menopause complaints. There are still few studies that compare the effectiveness of the two to improve quality of life. This study was to compare red clover with fish oil supplementation to improve the QOL in postmenopausal women. The quasi-experimental study with a nonequivalent control group design of 60 postmenopausal women was conducted. Participants were selected by consecutive sampling and equally divided into two groups. Each group was given red clover 400 mg once a day and fish oil supplementation 1000 mg (contains omega-3 marine triglycerides 300 mg as Eicosapentaenoic Acid (EPA) 180 mg and Docosahexaenoic Acid (DHA) 120 mg) once a day for twelve weeks. Quality of life was assessed using WHOQOL-BREF and postmenopausal complaints using a menopause rating scale questionnaire. The data were analyzed by Mann-Whitney U test, Wilcoxon Signed Rank test, and paired sample t-test. The mean (standard deviation) scores of the menopause rating scale (MRS) in the fish oil group were lower (2.10 [3.30]) than in the red clover group (3.97 [5.15]); p = 0.100. There were differences in QOL scores in the domain of psychical health (p=0.006), psychological (0.005), social relationships (0.010), and environment (0.010) in the fish oil group. In contrast, in the red clover group, differences were found in the domain of psychological (p=0.020), social relationships (0.022), and environment (0.002). There was no difference between the two groups.Fish oil supplementation was as effective as red clover to improve quality of life. Fish oil and red clover supplementation should be given to postmenopausal women with menopause complaints.
References
World Health Organization. RESEARCH ON THE MENOPAUSE Report of a WHO Scientific Group. Geneva; 1981.
Sherman S. Defining the menopausal transition. Am J Med. 2005;118(12 SUPPL. 2):3–7.
Kim MR, Kim HJ, Yu SH, Lee BS, Jeon SY, Lee JJ, et al. Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model. Evidence-based Complement Altern Med. 2020;2020.
Aidelsburger P, Schauer S, Grabein K, Wasem J. Alternative methods for the treatment of post-menopausal troubles. GMS Health Technol Assess. 2012;8:1–9.
Shirvani M, Heidari M. Quality of Life in Postmenopausal Female Members and Non-members of the Elderly Support Association. J Menopausal Med. 2016;22(3):154–60.
Gold EB, Colvin A, Avis N, Bromberger J, Greendale GA, Powell L, et al. Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: Study of women’s health across the nation. Am J Public Health. 2006;96(7):1226–35.
Johnson A, Roberts L, Elkins G. Complementary and Alternative Medicine for Menopause. J Evidence-Based Integr Med. 2019;24:1–14.
Geller SE, Studee L. Botanical and Dietary Supplements for Menopausal Symptoms: What Works, What Doesn’t. J Womens Heal. 2005;14(7):634–49.
Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and their bioactive phytochemicals for women’s health. Pharmacol Rev. 2016;68(4):1026–73.
Malca-Garcia GR, Zagal D, Graham J, Nikolic D, Friesen JB, Lankin DC, et al. Dynamics of the isoflavone metabolome of traditional preparations of Trifolium pratense L. J Ethnopharmacol. 2019;238:111865.
Shakeri F, Taavoni S, Haghani H, Gooshe G. The effect of red clover on severity of physical menopause symptoms. J Res Dev Nurs Midwifery. 2013;(Special Issue of the Sixth Seminar on Nursing, Midwifery Research):75–80.
Lipovac M, Chedraui P, Gruenhut C, Gocan A, Kurz C, Neuber B, et al. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Gynecol Endocrinol. 2012;28(3):203–7.
Shakeri F, Taavoni S, Goushegir A, Haghani H. Effectiveness of red clover in alleviating menopausal symptoms: A 12-week randomized, controlled trial. Climacteric. 2015;18(4):568–73.
Franco OH, Chowdhury R, Troup J, Voortman T, Kunutsor S, Kavousi M, et al. Use of plant-based therapies and menopausal symptoms: A systematic review and meta-analysis. JAMA - J Am Med Assoc. 2016;315(23):2554–63.
Wu B, Song Q, Zhang Y, Wang C, Yang M, Zhang J, et al. Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: Role of neuroinflammation and microglial polarization. Lipids Health Dis. 2020;19(1):1–10.
Farioli-Vecchioli S, Sacchetti S, di Robilant N V., Cutuli D. The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly. Curr Neuropharmacol. 2018;16(3):308–26.
Ciappolino V, Mazzocchi A, Enrico P, Syrén ML, Delvecchio G, Agostoni C, et al. N-3 polyunsatured fatty acids in menopausal transition: A systematic review of depressive and cognitive disorders with accompanying vasomotor symptoms. Int J Mol Sci. 2018;19(7):1–14.
Freeman MP, Hibbeln JR, Silver M, Hirschberg AM, Wang B, Yule AM, et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: A preliminary open trial. Menopause. 2011;18(3):279–84.
Lucas M, Dodin S, Poulin MJ, Mérette C. Does omega-3 improve menopausal symptoms? Agro Food Ind Hi Tech. 2009;20(4 SUPPL):14–7.
Cohen LS, Joffe H, Guthrie KA, Ensrud KE, Freeman M, Carpenter JS, et al. Efficacy of omega-3 for vasomotor symptoms treatment: A randomized controlled trial. Menopause. 2014;21(4):347–54.
Lemeshow S, Hosmer DW, Klar J, Lwanga SK. Adequacy of Sample Size in Health Studies. John Wiley & Sons Ltd. West Sussex: John Wiley & Sons Ltd.; 1990. 39 p.
Dwi Susanti H, Chang PC, Chung MH. Construct validity of the Menopause Rating Scale in Indonesia. Climacteric. 2019;22(5):454–9.
Purba FD, Hunfeld JAM, Iskandarsyah A, Fitriana TS, Sadarjoen SS, Passchier J, et al. Quality of life of the Indonesian general population: Test-retest reliability and population norms of the EQ-5D-5L and WHOQOL-BREF. PLoS One. 2018;13(5):1–20.
Moradi R, Roudi MA, Kiani MM, Mousavi Rigi SA, Mohammadi M, Keshvari M, et al. Investigating the Relationship between Self-efficacy and Quality of Life in Breast Cancer Patients Receiving Chemical Therapy. Bali Med J. 2017;6(1):6.
Subagya AN, Artanty W, Hapsari ED. Correlation between self-esteem and quality of life in menopausal women. J Persat Perawat Nas Indones. 2018;2(3):177.
Ehsanpour S, Salehi K, Zolfaghari B, Bakhtiari S. The effects of red clover on quality of life in post-menopausal women. [Internet]. Vol. 17, Iranian journal of nursing and midwifery research. 2012. p. 34–40. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23493172%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3590693
Ghazanfarpour M, Sadeghi R, Abdolahian S, Roudsari RL. The efficacy of Iranian herbal medicines in alleviating hot flashes: A systematic review. Int J Reprod BioMed. 2016;14(3):155–66.
Czuczwar P, Paszkowski T, Lisiecki M, Woźniak S, Stȩpniak A. The safety and tolerance of phytotherapies in menopausal medicine - A review of the literature. Menopause Rev/Przeglad Menopauzalny. 2017;16(1):8–11.
Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev. 2013;2013(12).
Appleton KM, Sallis HM, Perry R, Ness AR, Churchill R. Omega-3 fatty acids for depression in adults (Intervention Review). Cochrane Collab. 2015;11(5):1–135.
Burhani MD, Rasenick MM. Fish oil and depression: The skinny on fats Mansoor. J Integr Neurosci. 2017;16(Suppl 1):S115–24.
Kargozar R, Azizi H, Salari R. A review of effective herbal medicines in controlling menopausal symptoms. Electron Physician [Internet]. 2017;9(11):5826–33. Available from: http://www.ephysician.ir
