Use of Medication in Outpatient Hypertension Patients

Andi Bulqiah; Budi Suprapti; Shafira muti  Ardiana; M. Yusuf  Alsagaff; Suharjono

doi:10.33096/woh.vi.66

Andi Bulqiah Program Magister Farmasi Klinik, Fakultas Farmasi, Universitas Airlangga
Budi Suprapti Departemen Farmasi Praktis, Fakultas Farmasi, Universitas Airlangga
Shafira muti Ardiana Departemen Farmasi Praktis, Fakultas Farmasi, Universitas Airlangga
M. Yusuf Alsagaff Departemen Kardiologi dan Kedokteran Vaskular, Rumah Sakit Universitas Airlangga
Suharjono Departemen Farmasi Praktis, Fakultas Farmasi, Universitas Airlangga

Keywords: Hypertension; drug use; antihypertensive medications

Abstract

Hypertension is a major risk factor for cardiovascular disease, there are 1.13 billion people in the world suffering from hypertension. Hypertension should be given special consideration due to its impact on both the short and long term, one of which is by providing appropriate pharmacological therapy. The purpose of this study is to ascertain the pattern of medication use in hypertensive patients. The current study is a retrospective observational study that examines drug use patterns in hypertensive patients with or without associated disease. Using time-limited sampling techniques, the study sample is drawn from an electronic prescription of outpatient hypertension patients at Universitas Airlangga Surabaya Hospital (RSUA) in March 2021. According to the findings of this study, the most frequently prescribed antihypertensive medications were beta-blockers (29,66 %), ARB (27,51 %), CCB (26,17 %), aldosterone antagonists (6,72 %), loop diuretics (5,78 %), ACEi (3,98 %), and central α₂ agonists (3,98 %) (0,14 % ). Antihypertension medications are prescribed singly or in combination. In hypertensive patients with co-morbidities, drugs other than antihypertensives will be prescribed to treat the co-morbidities. The most frequently prescribed non-antihypertensive drugs are antihyperlipidemia statin (45,1 %), platelet antiagregation (19,1%), and antiangina (13,8 %). The study concludes that antihypertension medications are used alone or in combination with up to five other antihypertensive medications, with the most common combination being three drugs in 45% of patients. Suggestions for this study are that it should be accompanied by direct patient identification to minimize the incidence of drug interactions and drug side effects in patients.

References

DAFTAR PUSTAKA

World Health Organization. Hypertension. 2019. Diakses Dari Https://www.who.int/News-Room/Fact-Sheets/Detail/Hypertension, Pada Tanggal 20 Januari 2021

Kementrian Kesehatan Republik Indonesia. Hasil Utama Riskesdas 2018. 2018

Muhadi. JNC 8 : Evidence-Based Guideline Penanganan Pasien Hipertensi Dewasa. Cermin Dunia Kedokteran. 2016;43(1):54–9.

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 Evidence-Based Guideline For The Management Of High Blood Pressure In Adults: Report From The Panel Members Appointed To The Eighth Joint National Committee (JNC 8). JAMA - J Am Med Assoc. 2014;311(5):507–20.

Saseen, JJ, Maclaughlin EJ. In: J.T. Dipiro, R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells And L.M. Posey, Eds. Pharmacotherapy: A Pathophysiologic Approach 10th Edition. USA: Mc Graw Hill. 2016

Barton M, Meyer MR. Postmenopausal Hypertension: Mechanisms And Therapy. Hypertension. 2009;54(1):11–8.

Maas AHEM, Franke HR. Women’s Health In Menopause With A Focus On Hypertension. Netherlands Hear J. 2009;17(2):68–72.

Putri NRIAT, Rekawati E, Wati DNK. Relationship Of Age, Gender, Hypertension History, And Vulnerability Perception With Physical Exercise Compliance In Elderly. Enferm Clin [Internet]. 2019;29:541–5. Available From: https://doi.org/10.1016/j.enfcli.2019.04.083

Rockwood MRH, Howlett SE. Blood Pressure In Relation To Age And Frailty. Can Geriatr J. 2011;14(1):2–7.

Tackling G, Borhade MB. Hypertensive Heart Disease. [Updated 2021 Jul 1]. In: Statpearls [Internet]. Treasure Island (FL): Statpearls Publishing; 2022 Jan-

Bell K., Twiggs J, Olin BR. Hypertension: The Silent Killer: Update JNC-8 Guideline Recommendations. Alabama Pharmacy Association. 2015. 1-7.

Larochelle P, Tobe SW, Lacourcière Y. Β-Blockers In Hypertension: Studies And Meta-Analyses Over The Years. Can J Cardiol. 2014;30(5 S):16–22.

Gerard Wilkins LB. Beta-Blockers For Cardiovascular Conditions: One Size Does Not Fit All Patients. Best Pract J New Zeal [Internet]. 2017;(June):1–7. Available From: Https://Bpac.Org.Nz/2017/Docs/Beta-Blockers.Pdf

Zheng Z, Shi H, Jia J, Li D, Lin S. A Systematic Review And Meta-Analysis Of Candesartan And Losartan In The Management Of Essential Hypertension. JRAAS - J Renin-Angiotensin-Aldosterone Syst. 2011;12(3):365–74.

Husain A, Azim Md Sabir MS, Mitra M, Bhasin PS. A Review On Candesartan: Pharmacological And Pharmaceutical Profile. J Appl Pharm Sci. 2011;1(10):12–7.

Mckeever RG, Hamilton RJ. Calcium Channel Blockers. [Updated 2021 Jul 25]. In: Statpearls [Internet]. Treasure Island (FL): Statpearls Publishing; 2022 Jan-.

Prasetyo, E YO, Wijayanti T. Evaluasi Penggunaan Obat Antihipertensi Pada Penyakit Hipertensi Di Rsud A . W . Sjahranie Samarinda Pada Tahun 2012 Dan 2013 Dengan Metode ATC / DDD. Farm Indones. 2015;12(1):23–32.

Sun W, Zhang H, Guo J, Zhang X, Zhang L, Li C, et al. Comparison Of The Efficacy And Safety Of Different ACE Inhibitors In Patients With Chronic Heart Failure. Med (United States). 2016;95(6):1–8.

Ellison D, Felker GM. Diuretic Treatment In Heart Failure--From Physiology To Clinical Trials. N Engl J Med. 2017; 377(20): 1964–1975.

Patibandla S, Heaton J, Kyaw H. Spironolactone. [Updated 2021 Jul 18]. In: Statpearls [Internet]. Treasure Island (FL): Statpearls Publishing; 2022 Jan-.

OMS. WHO Recommendations On Drug Treatment For Non-Severe Hypertension In Pregnancy [Internet]. World Health Organization 2020. 2020. 83 P. Available From: https://www.who.int/Publications/I/Item/9789240008793

Dalal J, Padmanabhan TNC, Jain P, Patil S, Vasnawala H, Gulati A. LIPITENSION : Interplay Between Dyslipidemia And Hypertension. Indian J Endocrinol Metab. 2012;16(2):240.

National Cholesterol Education Program. ATP III Guidelines At-A-Glance Quick Desk Reference. NIH Publication. 2001; 1-7.

Zehnder JL. Drugs Used In Disorders Of Coagulation. In: B.G. Katzung. Basic & Clinical Pharmacology 14th Ed. USA: Mc Graw Hill. 2018; 608-610.

Persatuan Dokter Hipertensi Indonesia. Konsensus Penatalaksanaan Hipertensi 2019. Indonesian Society Of Hypertension. 2019;1–118.

Masriadi , Hasta Handayani Idrus , Alfina Baharuddin, Determinan Epidemiologi Kejadian Hipertensi Kehamilan , Window of Health : Jurnal Kesehatan, Vol. 5 No. 2 (April, 2022) : 592-601 URL artikel: http://jurnal.fkmumi.ac.id/index.php/woh/article/view/woh5210

Schwinghammer TL. Hypertension. In: B.G. Wells, J.T. Dipiro, T.L Schwinghammer, and C.V. Dipiro, Eds. Pharmacoterapy Handbook Ninth Edition. USA: Mc Graw Hill. 2015; 92-95.